The Fort Mojave Indian Reservation is an Indian reservation along the Colorado River, currently encompassing 23,669 acres in Arizona, 12,633 acres in California, and 5,582 acres in Nevada. The reservation was originally established in 1870 and is now home to approximately 1,100 members of the Mohave Tribe of Native Americans.

Occupancy on Fort Mojave Indian Reservation lands, unlike that of many other Indian reservations in Arizona, is less than 50% Native American. The Mojave have leased much of their land to cotton, corn, and soybean farming companies, which employ a large population of resident whites and Mexican Americans.